Basic Neurochemistry 8th Edition Principles of Molecular, Cellular, and Medical Neurobiology, pdf, ebook and download written by Scott Brady, George Siegel, R. Wayne Albers and Donald Price reflects the expanded attention to these links between neurochemistry and neurologic disease. The book has been the worldwide standard for information on the biochemistry of the nervous system, serving as a resource for postgraduate trainees and teachers in neurology, psychiatry, and basic neuroscience, as well as for medical, graduate, and postgraduate students and instructors in the neurosciences.
The Eighth Edition continues to cover the basics of neurochemistry as in the earlier editions, and updated text with new authors and material, and many entirely new chapters, over 400 fully revised figures in splendid color, there are 61 chapters covering the range of cellular, molecular and medical neuroscience and translational science boxes emphasizing the connections between basic and clinical neuroscience.
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The 8e is the updated version of the outstanding and comprehensive classic text on neurochemistry. For more than forty years, this text has been the worldwide standard for information on the biochemistry of the nervous system, serving as a resource for postgraduate trainees and teachers in neurology, psychiatry, and basic neuroscience, as well as for medical, graduate, and postgraduate students and instructors in the neurosciences.
Table of Contents
Associate Editors
List of Boxes
Sections
List of Contributors
Eighth Edition Acknowledgments and History
Preface to the Eighth Edition
Part I: Cellular Neurochemistry and Neural Membranes
Chapter 1. Cell Biology of the Nervous System
Overview
Cellular Neuroscience is the Foundation of Modern Neuroscience
Neurons: Common Elements and Diversity
Macroglia: More than Meets the Eye
Microglia
Blood–Brain Barriers and the Nervous System
The Neurovascular Unit Includes Multiple Components
Acknowledgements
References
Chapter 2. Cell Membrane Structures and Functions
Phospholipid Bilayers
Membrane Proteins
Biological Membranes
References
Chapter 3. Membrane Transport
Introduction
Primary Active Transport (P-Type) Pumps
Na,K-Adenosinetriphosphatase (Na,K-ATPase)
Ca Adenosinetriphosphatases and Na,Ca Antiporters
The Primary Plasma Membrane Ca Transporter (PMCA)
Smooth Endoplasmic Reticulum Calcium Pumps (SERCA)
Other P-Type Transporters
V0V1 Proton Pumps
ATP-Binding Cassettes
Secondary Active Transport
General Physiology of Neurotransmitter Uptake and Storage
The Cation Antiporters
The Anion Antiporters
Facilitated Diffusion: Aquaporins and Diffusion of Water
Facilitated Diffusion of Glucose and Myoinositol
References
Chapter 4. Electrical Excitability and Ion Channels
Membrane Potentials and Electrical Signals in Excitable Cells
Action Potentials in Electrically Excitable Cells
Functional Properties of Voltage-Gated Ion Channels
The Voltage-Gated Ion Channel Superfamily
The Molecular Basis for Ion Channel Function
Ion Channel Diversity
Acknowledgments
References
Chapter 5. Lipids
Introduction
Properties of Brain Lipids
Complex Lipids
Analysis of Brain Lipids
Brain Lipid Biosynthesis
Genes for Enzymes Catalyzing Synthesis and Degradation of Lipids
Lipids in the Cellular Milieu
Summary
Acknowledgments
References
Chapter 6. The Cytoskeleton of Neurons and Glia
Introduction
Molecular Components of the Neuronal Cytoskeleton
Ultrastructure and Molecular Organization of Neurons and Glia
Cytoskeletal Structures in the Neuron Have Complementary Distributions and Functions
Summary
References
Chapter 7. Intracellular Trafficking
Introduction
General Mechanisms of Intracellular Membrane Trafficking in Mammalian Cells Include Both Universal and Highly Specialized Processes
Fundamentals of Membrane Trafficking are Based on a set of Common Principles
The biosynthetic Secretory Pathway Includes Synthetic, Processing, Targeting and Secretory Steps
The Endocytic Pathway Plays Multiple Roles in Cells of the Nervous System
Synaptic Vesicle Trafficking is a Specialized Form of Regulated Secretion and Recycling Optimized for Speed and Efficiency
Acknowledgments
References
Chapter 8. Axonal Transport
Introduction
Neuronal Organelles in Motion
Discovery and Development of the Concept of Fast and Slow Components of Axonal Transport
Fast Axonal Transport
Slow Axonal Transport
Molecular Motors: Kinesin, Dynein and Myosin
AXONAL Transport and Neuropathology
Acknowledgments
References
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Book Details
No. of pages: 1120
Language: English
Copyright: © Academic Press 2011
Published: 2nd November 2011
Imprint: Academic Press
Hardcover ISBN: 9780123749475
eBook ISBN: 9780080959016
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