The Basic Neurochemistry 8th Edition by Scott Brady

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Basic Neurochemistry 8th Edition Principles of Molecular, Cellular, and Medical Neurobiology, pdf, ebook and download written by Scott Brady, George Siegel, R. Wayne Albers and Donald Price reflects the expanded attention to these links between neurochemistry and neurologic disease. The book has been the worldwide standard for information on the biochemistry of the nervous system, serving as a resource for postgraduate trainees and teachers in neurology, psychiatry, and basic neuroscience, as well as for medical, graduate, and postgraduate students and instructors in the neurosciences.

The Eighth Edition continues to cover the basics of neurochemistry as in the earlier editions, and updated text with new authors and material, and many entirely new chapters, over 400 fully revised figures in splendid color, there are 61 chapters covering the range of cellular, molecular and medical neuroscience and translational science boxes emphasizing the connections between basic and clinical neuroscience.

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The 8e is the updated version of the outstanding and comprehensive classic text on neurochemistry. For more than forty years, this text has been the worldwide standard for information on the biochemistry of the nervous system, serving as a resource for postgraduate trainees and teachers in neurology, psychiatry, and basic neuroscience, as well as for medical, graduate, and postgraduate students and instructors in the neurosciences.

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Table of Contents

Associate Editors

List of Boxes

Sections

List of Contributors

Eighth Edition Acknowledgments and History

Preface to the Eighth Edition

Part I: Cellular Neurochemistry and Neural Membranes

Chapter 1. Cell Biology of the Nervous System

Overview

Cellular Neuroscience is the Foundation of Modern Neuroscience

Neurons: Common Elements and Diversity

Macroglia: More than Meets the Eye

Microglia

Blood–Brain Barriers and the Nervous System

The Neurovascular Unit Includes Multiple Components

Acknowledgements

References

Chapter 2. Cell Membrane Structures and Functions

Phospholipid Bilayers

Membrane Proteins

Biological Membranes

References

Chapter 3. Membrane Transport

Introduction

Primary Active Transport (P-Type) Pumps

Na,K-Adenosinetriphosphatase (Na,K-ATPase)

Ca Adenosinetriphosphatases and Na,Ca Antiporters

The Primary Plasma Membrane Ca Transporter (PMCA)

Smooth Endoplasmic Reticulum Calcium Pumps (SERCA)

Other P-Type Transporters

V0V1 Proton Pumps

ATP-Binding Cassettes

Secondary Active Transport

General Physiology of Neurotransmitter Uptake and Storage

The Cation Antiporters

The Anion Antiporters

Facilitated Diffusion: Aquaporins and Diffusion of Water

Facilitated Diffusion of Glucose and Myoinositol

References

Chapter 4. Electrical Excitability and Ion Channels

Membrane Potentials and Electrical Signals in Excitable Cells

Action Potentials in Electrically Excitable Cells

Functional Properties of Voltage-Gated Ion Channels

The Voltage-Gated Ion Channel Superfamily

The Molecular Basis for Ion Channel Function

Ion Channel Diversity

Acknowledgments

References

Chapter 5. Lipids

Introduction

Properties of Brain Lipids

Complex Lipids

Analysis of Brain Lipids

Brain Lipid Biosynthesis

Genes for Enzymes Catalyzing Synthesis and Degradation of Lipids

Lipids in the Cellular Milieu

Summary

Acknowledgments

References

Chapter 6. The Cytoskeleton of Neurons and Glia

Introduction

Molecular Components of the Neuronal Cytoskeleton

Ultrastructure and Molecular Organization of Neurons and Glia

Cytoskeletal Structures in the Neuron Have Complementary Distributions and Functions

Summary

References

Chapter 7. Intracellular Trafficking

Introduction

General Mechanisms of Intracellular Membrane Trafficking in Mammalian Cells Include Both Universal and Highly Specialized Processes

Fundamentals of Membrane Trafficking are Based on a set of Common Principles

The biosynthetic Secretory Pathway Includes Synthetic, Processing, Targeting and Secretory Steps

The Endocytic Pathway Plays Multiple Roles in Cells of the Nervous System

Synaptic Vesicle Trafficking is a Specialized Form of Regulated Secretion and Recycling Optimized for Speed and Efficiency

Acknowledgments

References

Chapter 8. Axonal Transport

Introduction

Neuronal Organelles in Motion

Discovery and Development of the Concept of Fast and Slow Components of Axonal Transport

Fast Axonal Transport

Slow Axonal Transport

Molecular Motors: Kinesin, Dynein and Myosin

AXONAL Transport and Neuropathology

Acknowledgments

References

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Book Details

No. of pages: 1120

Language: English

Copyright: © Academic Press 2011

Published: 2nd November 2011

Imprint: Academic Press

Hardcover ISBN: 9780123749475

eBook ISBN: 9780080959016

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